Neurotensin and substance P and dumping syndrome.

Elevation of plasma neurotensin in the dumping syndrome.

1. The pathophysiology of the dumping syndrome is poorly understood. Plasma levels of four small intestinal hormones have been measured after an oral glucose provocation test in 19 patients with dumping symptoms and in matched controls. 2. Plasma levels of neurotensin, a newly discovered highly potent, hypotensive ileal peptide, were significantly increased in symptomatic patients compared with...

دمپینگ سندرم (Dumping Syndrome)

Neurotensin and substance P, originally isolated from bovine hypothalamus (Carraway and Leeman 1973) and from equine hypothalamus and intestine (Euler

ITO, S., IWASAKI, Y., MOMOTSU, T., TAKAI, K., SHIBATA, A., MATSUBARA, Y, and MUTO, T. Neurotensin and Substance P and Dumping Syndrome. Tohoku J. exp. Med., 1981, 135 (1), 11-21 To investigste the pathophysiological relation between releases of gut hormones and dumping syndrome, plasma radioimmunoassayable neurotesin, substance P, glucagon-like immunoreactivity (GLI), insulin and blood sugar we...

Substance P and neurotensin: discovery, isolation, chemical characterization and physiological studies.

During the course of work directed towards the purification of a corticotropin-releasing factor, two other biological active substances were discovered in bovine hypothalamic extracts: one a sialogogic peptide, the other a vaso-active substance easily separated from the sialogogic agent by ion-exchange chromotography. The sialogogic peptide was subsequently characterized as substance P (SP); th...

Behavioral effects of hypothalamic hypophysiotropic hormones, neurotensin, substance P and other neuropeptides.

CHARLES B. NEMEROFF,* PETER W. KALIVAS,'~ ROBERT N. GOLDEN~ a n d ARTHUR J. PRANGE, JR.§ *Duke University Medical Center, Durham, North Carolina 27710, U.S.A., tDepartment of Pharmacology, Louisiana State University Medical Center, New Orleans, Louisiana, U.S.A., ~National Institute of Mental Health, Bethesda, MD 20205, U.S.A. and §University of North Carolina School of Medicine, Chapel Hill, N...